Azithromycin, marketed under the brand name Denk, is a macrolide antibiotic that is effective against a variety of bacterial infections. It works by inhibiting bacterial protein synthesis, which halts the growth of bacteria. Azithromycin is commonly prescribed for respiratory infections, skin infections, and sexually transmitted diseases.
Indications
Azithromycin 500 mg is indicated for:
- Respiratory Tract Infections: Such as pneumonia and bronchitis.
- Ear Infections: Including acute otitis media.
- Skin and Soft Tissue Infections: Such as cellulitis and impetigo.
- Sexually Transmitted Infections: Including chlamydia and gonorrhea.
Dosage
- Adults: The typical dosage is 500 mg on the first day, followed by 250 mg once daily for the next 4 days (totaling 1.5 g). For some infections, a single dose of 1 g may be prescribed.
- Children: Dosing is generally based on body weight and should be determined by a healthcare provider, typically around 10 mg/kg once daily for 3 days.
Administration
- How to Use: Azithromycin tablets should be taken orally with or without food. It is advisable to take them at the same time each day for consistent results.
- Missed Dose: If a dose is missed, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Common Side Effects
Possible side effects may include:
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
Serious side effects can include:
- Allergic reactions (e.g., rash, swelling, difficulty breathing)
- Liver problems (e.g., jaundice)
- Heart rhythm changes (QT prolongation)
Warnings and Precautions
- Contraindications: Not suitable for individuals with a known allergy to azithromycin or other macrolide antibiotics.
- Liver Function: Use with caution in patients with liver impairment; monitoring may be necessary during treatment.
- Heart Rhythm Issues: Azithromycin may cause QT prolongation; use with caution in patients with existing heart conditions or those taking medications that affect heart rhythm.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if you are pregnant or breastfeeding.
Drug Interactions
Inform your healthcare provider about all medications you are taking, especially:
- Antacids containing aluminum or magnesium (may interfere with absorption)
- Other medications that prolong QT interval
Storage
Store Azithromycin tablets at room temperature (15° to 30°C), away from moisture and direct sunlight. Keep out of reach of children.
