Bactoclav is a combination antibiotic that contains amoxicillin and clavulanic acid. It is designed to treat a variety of bacterial infections by leveraging the properties of both components. Amoxicillin is a penicillin-type antibiotic that inhibits bacterial cell wall synthesis, while clavulanic acid acts as a beta-lactamase inhibitor, protecting amoxicillin from degradation by certain bacteria.
Indications
Bactoclav 375 mg is indicated for the treatment of:
- Respiratory Tract Infections: Such as pneumonia and bronchitis.
- Ear Infections: Including acute otitis media.
- Skin and Soft Tissue Infections: Such as cellulitis and abscesses.
- Urinary Tract Infections: Including cystitis and pyelonephritis.
- Dental Infections: Severe dental infections with spreading cellulitis.
- Intra-abdominal Infections: Such as those associated with appendicitis.
Dosage
- Adults: The usual dosage is 1 tablet (375 mg) every 8 hours for most infections. For more severe infections, higher doses may be recommended.
- Children: Dosing should be based on body weight and determined by a healthcare provider, typically around 20–40 mg/kg/day divided into two or three doses.
Administration
- How to Use: Bactoclav tablets can be taken with or without food. However, taking them at the start of a meal may enhance absorption and reduce gastrointestinal discomfort.
- Missed Dose: If a dose is missed, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Common Side Effects
Possible side effects may include:
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Skin rash
Serious side effects can include:
- Allergic reactions (e.g., hives, swelling, difficulty breathing)
- Liver problems (e.g., jaundice)
- Clostridium difficile-associated diarrhea
Warnings and Precautions
- Contraindications: Not suitable for individuals with a known allergy to penicillin or cephalosporins.
- Liver Function: Use with caution in patients with liver impairment; liver function should be monitored during treatment.
- Kidney Function: Caution is advised in patients with renal impairment; dosage adjustments may be necessary.
- Pregnancy and Breastfeeding: Generally considered safe during pregnancy and breastfeeding, but consult a healthcare provider before use.
Drug Interactions
Inform your healthcare provider about all medications you are taking, especially:
- Anticoagulants (e.g., warfarin) may have increased effects when taken with Bactoclav.
- Probenecid may increase levels of amoxicillin.
Storage
Store Bactoclav tablets at room temperature (15° to 30°C), away from moisture and direct sunlight. Keep out of reach of children.
