Cefuroxime syrup is an oral suspension that contains cefuroxime axetil, a second-generation cephalosporin antibiotic. This formulation is typically used to treat various bacterial infections, particularly in pediatric patients.
Key Uses
Cefuroxime syrup is indicated for the treatment of:
- Respiratory Tract Infections: Such as pneumonia and bronchitis.
- Ear Infections: Including otitis media.
- Skin and Soft Tissue Infections: Effective against conditions like cellulitis and abscesses.
- Urinary Tract Infections (UTIs): Treats infections of the urinary system.
- Gonorrhea: Used for treating uncomplicated gonococcal infections.
Mechanism of Action
Cefuroxime works by inhibiting bacterial cell wall synthesis, which is essential for bacterial growth and survival. This action leads to the weakening and eventual death of the bacteria, helping to clear the infection.
Dosage and Administration
- Adults: The typical dosage for adults is usually 500 mg every 12 hours, depending on the type and severity of the infection.
- Children: For pediatric patients, the dosage is generally based on weight, often around 20-30 mg/kg/day, divided into two doses.
The syrup should be shaken well before use and can be taken with or without food. Taking it with food may help enhance absorption.
Side Effects
Common side effects may include:
- Nausea
- Diarrhea
- Abdominal pain
- Dizziness
- Allergic reactions (rash, itching)
Serious side effects can include severe allergic reactions, liver dysfunction, and Clostridium difficile-associated diarrhea.
Warnings and Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to cefuroxime or other cephalosporins. Caution is advised for those with a history of penicillin allergy.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
- Renal Impairment: Dosage adjustments may be necessary for patients with kidney issues.
Storage
Store cefuroxime syrup at room temperature (below 25°C), away from moisture and direct sunlight. After reconstitution, it should typically be refrigerated and used within a specified period (usually within 14 days).
