Clavulin is a combination antibiotic that contains amoxicillin and clavulanic acid. The 228 mg/5 ml syrup formulation is designed for oral administration and is commonly used to treat a variety of bacterial infections.
Key Uses
Clavulin syrup is indicated for the treatment of:
- Upper Respiratory Tract Infections: Such as sinusitis and otitis media (ear infections).
- Lower Respiratory Tract Infections: Including pneumonia and bronchitis.
- Urinary Tract Infections: Effective for infections like cystitis and pyelonephritis.
- Skin and Soft Tissue Infections: Such as cellulitis and abscesses.
- Dental Infections: Including severe dental abscesses.
Mechanism of Action
- Amoxicillin: A penicillin-type antibiotic that works by inhibiting bacterial cell wall synthesis, leading to cell death.
- Clavulanic Acid: A beta-lactamase inhibitor that protects amoxicillin from degradation by certain bacteria that produce beta-lactamase enzymes. This combination enhances the effectiveness of amoxicillin against resistant bacterial strains.
Dosage and Administration
- Adults and Children (over 12 weeks): The dosage is typically based on the severity of the infection and the patient's weight. Common dosing guidelines include:
- For mild to moderate infections: 20 mg/kg/day divided into two doses every 12 hours.
- For severe infections: Up to 45 mg/kg/day divided into two doses every 12 hours.
For children weighing less than 40 kg, the dose should be calculated based on body weight.
Side Effects
Common side effects may include:
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Skin rash
Serious side effects are rare but can include:
- Severe allergic reactions (anaphylaxis)
- Liver dysfunction
- Clostridium difficile-associated diarrhea
Warnings and Precautions
- Contraindications: Not suitable for individuals with a known hypersensitivity to amoxicillin, clavulanic acid, or other beta-lactam antibiotics.
- Caution in Specific Populations: Use cautiously in patients with liver disease or those with a history of antibiotic-associated colitis.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
Storage
Store Clavulin syrup at room temperature (below 25°C), away from moisture and direct sunlight. Once reconstituted, it should be used within the specified time frame as indicated on the packaging.
