Duragesic is a brand name for the fentanyl transdermal system, which is primarily used for the management of chronic pain in patients who are already opioid-tolerant. Each pack typically contains 10 tablets, although Duragesic is more commonly known in its patch form rather than as tablets.
Key Features
- Active Ingredient: Fentanyl, a potent synthetic opioid analgesic.
- Formulation: While the search results predominantly discuss the transdermal patch, it’s important to note that fentanyl is also available in other forms, including lozenges and injectable solutions.
Indications
Duragesic is indicated for:
- Chronic Pain Management: Used in patients who require continuous opioid analgesia and have developed tolerance to other opioids.
- Severe Pain Relief: Effective for patients with severe pain that cannot be managed by non-opioid medications.
Mechanism of Action
Fentanyl works by binding to the mu-opioid receptors in the brain, altering the perception of pain and emotional response to pain. This results in significant pain relief and sedation.
Dosage and Administration
- Recommended Dosage: The dosage of Duragesic should be individualized based on the patient’s previous opioid use and overall medical condition.
- Administration Instructions:
- If using the transdermal patch, apply it to clean, dry, intact skin on a flat surface (e.g., chest, back, or upper arm).
- The patch is typically changed every 72 hours, but specific instructions should be followed based on individual treatment plans.
Side Effects
Common side effects may include:
- Drowsiness or sedation
- Nausea and vomiting
- Constipation
- Dizziness
Serious side effects can include:
- Respiratory depression (slow or difficult breathing)
- Severe allergic reactions (e.g., rash, swelling)
- Dependence or withdrawal symptoms with prolonged use
If any severe reactions occur, discontinue use immediately and seek medical attention.
Precautions
- Contraindications: Duragesic should not be used in individuals who are not opioid-tolerant or those with severe respiratory disorders.
- Caution Required: Use with caution in elderly patients or those with liver or kidney impairment. Regular monitoring may be necessary during treatment.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding due to potential risks to the fetus or infant.
