Genta 80mg Injection, also known as Gentamicin, is an aminoglycoside antibiotic used to treat a variety of serious bacterial infections. It is particularly effective against Gram-negative bacteria and is often employed in hospital settings for its broad-spectrum activity.
Key Features
- Dosage: Each vial contains 80 mg of Gentamicin.
- Administration: The injection can be administered intravenously (IV) or intramuscularly (IM), typically under the supervision of a healthcare professional.
Indications
Genta 80mg Injection is indicated for:
- Urinary Tract Infections (UTIs): Effective in treating complicated UTIs caused by susceptible bacteria.
- Respiratory Infections: Used for pneumonia and other lung infections.
- Sepsis: Management of severe infections that can lead to systemic inflammatory response syndrome.
- Bone and Joint Infections: Treatment of osteomyelitis and septic arthritis.
- Meningitis: Used in conjunction with other antibiotics to treat infections of the central nervous system.
- Skin and Soft Tissue Infections: Effective against serious skin infections.
Mechanism of Action
Gentamicin works by inhibiting bacterial protein synthesis, which is essential for bacterial growth and reproduction. This action effectively kills or stops the growth of bacteria, helping to clear the infection.
Dosage and Administration
- Recommended Dosage:
- The dosage varies based on the type and severity of the infection, as well as patient factors such as age and kidney function. Typical dosing may range from 3 to 5 mg/kg/day, divided into multiple doses.
- Administration Instructions:
- Administered by healthcare professionals either as a slow intravenous infusion or intramuscular injection.
- It is crucial to monitor kidney function and hearing during treatment due to potential side effects.
Side Effects
Common side effects may include:
- Hearing loss or tinnitus (ringing in the ears).
- Kidney damage, especially with prolonged use or in patients with pre-existing kidney conditions.
- Injection site reactions, such as pain or swelling.
- Balance disorders due to inner ear effects.
Serious side effects are rare but can include:
- Severe allergic reactions (e.g., rash, difficulty breathing).
- Neuromuscular blockade leading to respiratory depression.
Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to Gentamicin or other aminoglycosides. Caution is advised in patients with renal impairment or those receiving other nephrotoxic drugs.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use; Gentamicin should only be used if clearly needed during pregnancy.
- Drug Interactions: Inform your doctor about all medications you are taking, as Gentamicin can interact with other drugs that affect kidney function.
