Metro 200mg Tablets are a formulation of Metronidazole, an antibiotic used to treat a variety of infections caused by anaerobic bacteria and certain protozoa. Each film-coated tablet contains 200 mg of Metronidazole and is indicated for both prophylactic and therapeutic use.
Key Uses
Metro 200mg Tablets are indicated for:
- Anaerobic Infections: Effective in treating infections caused by anaerobic bacteria, such as Bacteroides, Clostridia, and Fusobacteria.
- Protozoal Infections: Treats infections like trichomoniasis, amoebiasis, and giardiasis.
- Post-Operative Prophylaxis: Used to prevent infections after surgical procedures, particularly those involving the gastrointestinal tract.
Mechanism of Action
Metronidazole works by diffusing into the cells of anaerobic bacteria and protozoa, where it is activated and forms free radicals that damage the DNA, leading to cell death. This action effectively inhibits the growth of the pathogens responsible for the infection.
Dosage and Administration
- Recommended Dosage:
- For adults, the typical dosage for treating established anaerobic infections may start with 800 mg, followed by 400 mg every 8 hours.
- For children aged 8 weeks to 12 years, the usual daily dose is 20-30 mg/kg/day, which can be given as a single dose or divided into three doses.
- Administration Instructions:
- Take the tablets with food to minimize gastrointestinal side effects.
- Swallow the tablet whole; do not crush or chew.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Diarrhea
- Abdominal pain or discomfort
- Dry mouth or metallic taste
Serious side effects can include:
- Allergic reactions (e.g., rash, swelling)
- Neurological symptoms such as seizures or peripheral neuropathy
- Liver dysfunction (e.g., jaundice)
Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to metronidazole or those with severe liver disease.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
- Drug Interactions: Inform your healthcare provider about all medications you are taking to avoid potential interactions, especially with alcohol, which can cause severe reactions when combined with metronidazole.
