Metro 400mg (Orvagil) is a formulation of Metronidazole, an antibiotic used to treat various infections caused by anaerobic bacteria and certain protozoa. This medication is particularly effective for conditions such as bacterial vaginosis, amoebiasis, and other gastrointestinal infections.
Key Uses
Metro 400mg Tablets are indicated for:
- Bacterial Infections: Effective against infections in the liver, stomach, intestines, vagina, brain, heart, lungs, bones, and skin.
- Protozoal Infections: Used to treat infections caused by Entamoeba histolytica (amoebic dysentery) and Trichomonas vaginalis (trichomoniasis).
- Post-Surgical Prophylaxis: Helps prevent infections after surgical procedures, especially those involving the gastrointestinal tract.
Mechanism of Action
Metronidazole works by entering the cells of anaerobic bacteria and protozoa, where it is activated to form free radicals that damage DNA, leading to cell death. This action effectively inhibits the growth of the pathogens responsible for the infection.
Dosage and Administration
- Recommended Dosage: The typical dosage may vary based on the specific condition being treated. Common regimens include:
- For bacterial vaginosis: 750 mg once daily for 7 days.
- For amoebiasis: 750 mg three times daily for 5 to 10 days.
- Administration Instructions:
- Take the tablets during or after meals to minimize gastrointestinal discomfort.
- Swallow the tablet whole; do not crush or chew.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Diarrhea
- Abdominal pain or discomfort
- Metallic taste in the mouth
- Dry mouth
Serious side effects can include:
- Allergic reactions (e.g., rash, swelling)
- Neurological symptoms such as seizures or peripheral neuropathy (tingling or numbness)
- Liver dysfunction (e.g., jaundice)
Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to metronidazole or those with severe liver disease.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
- Drug Interactions: Inform your healthcare provider about all medications you are taking to avoid potential interactions, particularly with alcohol, which can cause severe reactions when combined with metronidazole.
Conclusion
Metro 400mg (Orvagil) tablets are an effective treatment option for various bacterial and protozoal infections. Proper adherence to prescribed dosages and awareness of potential side effects are crucial for safe use. Always consult your healthcare provider for personalized advice regarding treatment options and any concerns about medication.
