Nicotinamide Mononucleotide (NMN) is a nucleotide derived from ribose and nicotinamide. It serves as a precursor to NAD+ (nicotinamide adenine dinucleotide), a crucial coenzyme involved in various cellular processes, including energy metabolism, DNA repair, and cellular signaling. As NAD+ levels naturally decline with age, NMN supplementation has gained attention for its potential anti-aging benefits.
Key Benefits of NMN Supplementation
1. Increases NAD+ Levels: NMN supplementation has been shown to raise NAD+ levels in the body, which can enhance mitochondrial function and energy production. Studies indicate that NAD+ levels can increase by approximately 40% after 30 days of NMN supplementation at a dose of 250 mg per day.
2. Supports Mitochondrial Health: By boosting NAD+ levels, NMN helps improve mitochondrial replication and function, which is vital for energy production in cells.
3. Improves Muscle Function: Clinical studies have demonstrated that NMN can enhance muscle strength and performance, particularly in older adults. This is linked to improved NAD+ levels associated with better muscle function.
4. Enhances Insulin Sensitivity: NMN has been shown to improve insulin sensitivity, which can help in managing blood sugar levels and reducing the risk of metabolic disorders.
5. Promotes Vascular Health: Supplementation with NMN may enhance blood flow and vascular health by improving endothelial function.
6. Potential Neuroprotective Effects: NMN may benefit brain health by improving neuronal function and protecting against age-related cognitive decline.
7. Anti-Aging Properties: Research suggests that NMN could delay aging-related physiological decline and promote longevity by enhancing cellular repair mechanisms and metabolic health.
8. Improves Eye Function: Some studies indicate that NMN may help restore normal function in retinal cells, potentially protecting against age-related eye diseases.
Recommended Dosage
- The typical dosage for adults ranges from 250 mg to 500 mg per day, with some studies suggesting that individuals over 65 years may take up to 750 mg per day.
Safety and Side Effects
- Current research indicates that NMN is generally safe for human consumption, with no significant side effects reported in clinical trials at doses up to 500 mg per day. However, ongoing studies are necessary to fully understand its long-term safety profile.
Dietary Sources
NMN is naturally found in small amounts in various foods, including:
- Avocados
- Broccoli
- Cabbage
- Tomatoes
- Raw beef
