Metronidazole 400mg tablets are an antibiotic medication used to treat a variety of infections caused by anaerobic bacteria and certain protozoa. This formulation is commonly used in clinical settings for its efficacy against various types of infections.
Key Uses
Metronidazole is indicated for:
- Bacterial Infections: Effective against infections in the stomach, intestines, liver, skin, joints, brain, heart, and respiratory tract.
- Protozoal Infections: Treats conditions such as amoebiasis (caused by Entamoeba histolytica) and trichomoniasis (caused by Trichomonas vaginalis).
- Gynecological Infections: Often used in the treatment of bacterial vaginosis and pelvic inflammatory disease.
- Post-Surgical Prophylaxis: Used to prevent infections following surgical procedures, especially those involving the gastrointestinal tract.
Dosage and Administration
- Recommended Dosage: The dosage may vary based on the specific condition being treated. Common regimens include:
- For anaerobic infections: 400 mg every 8 hours for 7 days.
- For trichomoniasis: A single dose of 2,000 mg or 400 mg every 8 hours for 7 days.
- Administration Instructions:
- Take the tablets with food to minimize gastrointestinal discomfort.
- Swallow the tablet whole; do not crush or chew.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Diarrhea
- Abdominal pain or discomfort
- Metallic taste in the mouth
- Dry mouth
Serious side effects can include:
- Allergic reactions (e.g., rash, swelling)
- Neurological symptoms such as seizures or peripheral neuropathy (tingling or numbness)
- Liver dysfunction (e.g., jaundice)
Precautions
- Contraindications: Avoid use in individuals with known hypersensitivity to metronidazole or those with severe liver disease.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
- Drug Interactions: Inform your healthcare provider about all medications you are taking to avoid potential interactions, especially with alcohol, which can cause severe reactions when combined with metronidazole.
