P-Alaxin TS is a combination medication used for the treatment of acute, uncomplicated malaria caused by Plasmodium falciparum, particularly in areas with multi-drug resistant strains. Each pack typically contains 3 tablets, making it suitable for a short course of treatment.
Key Ingredients
- Dihydroartemisinin (120 mg): A potent antimalarial agent derived from artemisinin, known for its rapid action against malaria parasites.
- Piperaquine Phosphate (960 mg): A longer-acting antimalarial that complements the action of dihydroartemisinin, helping to eliminate residual parasites and prevent reinfection.
Mechanism of Action
- Dihydroartemisinin works by rapidly reducing the parasite load in the bloodstream, interfering with the parasite's ability to detoxify heme, which is toxic to them.
- Piperaquine has a longer half-life, allowing it to continue working after dihydroartemisinin has cleared the initial infection, thus providing extended protection against reinfection.
Dosage and Administration
- Recommended Dosage: The typical dosage for adults and children weighing 36 kg or more is 1 tablet once daily for 3 consecutive days.
- Administration Instructions: Take the tablets with water on an empty stomach, ideally at least 3 hours before or after a meal to ensure optimal absorption.
Side Effects
Common side effects may include:
- Headache
- Dizziness
- Nausea
- Abdominal pain
- Fatigue
Serious side effects are rare but can include:
- Severe allergic reactions (e.g., rash, swelling)
- Abnormal heart rhythms (QT prolongation)
- Liver problems
If severe side effects occur, seek medical attention immediately.
Precautions
- Contraindications: Not recommended for patients with severe malaria or certain heart conditions. Use caution in individuals with liver or kidney impairment.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.
- Drug Interactions: Inform your healthcare provider about all medications you are taking, especially those affecting heart rhythm.
