P-Alaxin is an antimalarial medication that combines Dihydroartemisinin and Piperaquine Phosphate. It is primarily used for the treatment of uncomplicated malaria, particularly caused by Plasmodium falciparum and other malaria species. Each pack typically contains 9 tablets, making it suitable for a short treatment course.
Key Ingredients
- Dihydroartemisinin (40 mg): A fast-acting antimalarial derived from artemisinin, effective in rapidly reducing the parasite load in the bloodstream.
- Piperaquine Phosphate (320 mg): A longer-acting antimalarial that helps to eliminate residual parasites and prevent reinfection.
Mechanism of Action
- Dihydroartemisinin works quickly to clear malaria parasites from the blood, while Piperaquine provides prolonged action to ensure that any remaining parasites are eliminated, thus reducing the risk of recurrence.
Dosage and Administration
- Recommended Dosage: The standard regimen involves taking 3 tablets once daily for 3 consecutive days. The dosage may vary based on the patient's weight:
- For adults weighing 36 to <60 kg: 3 tablets per day.
- For those weighing 60 to <80 kg: 4 tablets per day.
- For patients over 80 kg: 5 tablets per day.
- Administration Instructions: It is recommended to take the tablets with water, preferably with food to minimize gastrointestinal discomfort.
Side Effects
Common side effects may include:
- Nausea
- Vomiting
- Dizziness
- Fatigue
- Abdominal pain
Serious side effects, although rare, can include:
- Allergic reactions (e.g., rash, swelling)
- Heart rhythm abnormalities (QT prolongation)
Precautions
- Contraindications: Not recommended for individuals with known allergies to dihydroartemisinin or piperaquine. Caution is advised for those with a history of heart problems or liver disease.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.
- Drug Interactions: Inform your healthcare provider about all medications you are taking, as P-Alaxin may interact with other drugs.
