Tranexamic Acid 500mg Tablets are an antifibrinolytic medication used primarily to reduce or prevent excessive bleeding in various clinical situations. It is particularly effective in managing heavy menstrual bleeding and other conditions associated with hyperfibrinolysis.
Key Features
- Active Ingredient: Each tablet contains 500mg of tranexamic acid.
- Packaging: Typically available in packs of 30 tablets.
Indications
Tranexamic acid is indicated for:
- Menorrhagia: Treatment of heavy menstrual bleeding in premenopausal women.
- Surgical Procedures: Used to reduce blood loss during surgeries, including dental extractions and orthopedic surgeries.
- Trauma and Postpartum Hemorrhage: Helps control bleeding in trauma cases and during or after childbirth.
- Hereditary Angioedema: Can be used to prevent attacks in patients with this condition.
Mechanism of Action
Tranexamic acid works by competitively inhibiting the activation of plasminogen to plasmin, preventing the breakdown of fibrin clots. This action stabilizes blood clots and reduces bleeding.
Dosage and Administration
- Recommended Dosage:
- For heavy menstrual bleeding: The typical dose is 1300 mg (two 650 mg tablets) taken three times a day for up to five days during menstruation.
- For surgical procedures: Doses may vary; typically, an initial dose of 10 mg/kg intravenously may be administered before surgery, followed by maintenance doses.
- Administration Tips: Tranexamic acid can be taken with or without food. It is important to follow the prescribed dosage and duration as directed by a healthcare provider.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Diarrhea or abdominal pain
- Headache
- Dizziness or fatigue
Serious side effects that require immediate medical attention include:
- Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
- Vision changes (e.g., blurred vision)
- Signs of thrombosis (e.g., swelling, pain in the legs)
Precautions
- Contraindications: Not recommended for individuals with a history of thromboembolic events, severe renal impairment, or known hypersensitivity to tranexamic acid.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use if pregnant or breastfeeding.
- Drug Interactions: Caution is advised when used with oral contraceptives or other medications that may increase the risk of thrombosis.
