Unitrim Syrup is a combination antibiotic medication that contains sulfamethoxazole and trimethoprim. This formulation is commonly used to treat various bacterial infections, particularly in pediatric patients.
Key Ingredients
- Sulfamethoxazole: 200 mg per 5 ml
- Trimethoprim: 40 mg per 5 ml
Indications
Unitrim Syrup is indicated for:
- Urinary Tract Infections (UTIs): Effective in treating uncomplicated UTIs.
- Respiratory Infections: Used for infections such as bronchitis and pneumonia.
- Ear Infections: Treats otitis media caused by susceptible bacteria.
- Traveler's Diarrhea: Can be used to manage diarrhea caused by certain bacteria.
Mechanism of Action
The combination of sulfamethoxazole and trimethoprim works synergistically to inhibit bacterial growth.
- Sulfamethoxazole interferes with the synthesis of folate in bacteria, which is essential for DNA and RNA synthesis.
- Trimethoprim further inhibits a different step in the folate synthesis pathway, enhancing the antibacterial effect.
Dosage and Administration
- Recommended Dosage for Children:
- 6 to 12 years: 10 ml every 12 hours.
- 6 months to 5 years: 5 ml every 12 hours.
- 6 weeks to 5 months: 2.5 ml every 12 hours.
- Administration Tips:
- Shake the bottle well before use.
- Use the provided measuring spoon for accurate dosing.
- It can be taken with or without food.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Loss of appetite
- Rash or itching
- Diarrhea
Serious side effects requiring immediate medical attention include:
- Severe allergic reactions (e.g., difficulty breathing, swelling)
- Skin reactions (e.g., blistering, peeling)
- Signs of liver problems (e.g., jaundice)
Precautions
- Contraindications: Not recommended for individuals with a known allergy to sulfa drugs or trimethoprim, or those with severe liver or kidney disease.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.
- Drug Interactions: Caution is advised when used with other medications that may affect kidney function or blood cell counts.
