Xithrone is an oral suspension containing azithromycin, a macrolide antibiotic used to treat various bacterial infections. The formulation typically comes in a 15ml bottle, making it suitable for pediatric and adult use.
Key Features
- Active Ingredient: Each 5ml of Xithrone syrup contains 200 mg of azithromycin.
- Formulation: A liquid suspension that is easy to administer, especially for children.
Indications
Xithrone is indicated for the treatment of:
- Respiratory Infections: Such as pneumonia, bronchitis, and sinusitis.
- Ear Infections: Acute otitis media caused by susceptible bacteria.
- Skin Infections: Including soft tissue infections.
- Genitourinary Infections: Such as non-gonococcal urethritis and cervicitis.
Mechanism of Action
Azithromycin works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit of the bacteria, effectively stopping their growth and reproduction. It is effective against a variety of gram-positive and gram-negative bacteria.
Dosage and Administration
- Recommended Dosage: The dosage may vary based on the type of infection:
- For most infections, a common regimen is 10 mg/kg on Day 1, followed by 5 mg/kg daily for the next 4 days.
- Administration Tips: Shake well before use. It can be taken with or without food, but taking it with food may help reduce gastrointestinal upset.
Side Effects
Common side effects may include:
- Nausea or vomiting
- Diarrhea or abdominal pain
- Headache
- Dizziness
Serious side effects requiring immediate medical attention include:
- Signs of an allergic reaction (e.g., rash, swelling, difficulty breathing)
- Severe diarrhea (watery or bloody), which may indicate Clostridium difficile infection
- Liver problems (e.g., yellowing of skin or eyes, dark urine)
Precautions
- Contraindications: Not suitable for individuals with known hypersensitivity to azithromycin or other macrolide antibiotics.
- Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.
- Drug Interactions: Inform your healthcare provider about any other medications being taken, especially those that may affect heart rhythm.
